The Role of VDR Gene Polymorphisms in Vitamin D Supplementation

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The vitamin D receptor (VDR) is a nuclear transcriptional regulator that activates by binding to 1a,25-dihydroxycholecalciferol (1a,25(OH)2D), known as calcitriol, which forms a heterodimer with the retinoid X receptor (RXR). Calcitriol signals are involved in various biological processes that include calcium and phosphorous metabolic processes as well as parathormone release, cellular proliferative processes, and the control of adaptive and innate immunity.

A T > C change in the promoter region of the VDR variant (rs11568820) removes the binding Cdx2’s transcription factor binding site just upstream of exon 1. This leads to a smaller protein with decreased transcriptional activity. The F allele of this variant can be found in high numbers in Asians and Europeans and at a low frequency in Sub-Saharan Africa.

The findings of this study advance our understanding of the role VDR gene polymorphisms can influence the response of dietary supplementation with calcium calcitriol. The carriers of the TaqI polymorphism and FF genotype of the FokI polymorphism show higher transcriptional activation of VDR and are associated with increased calcium absorption and bone mineral density as well as reduced risk of fractures [34 35, 34[34, 35]. Further research with an unbiased design is required to increase our understanding of how these genetic variants influence vitamin learn the facts here now D supplementation and its clinical significance.

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